It´s a form of thrombotic microangiopathy, characterized by anemia, thrombocytopenia and acute renal impairment of varying severity, which may be preceded by an episode of diarrhea with or without blood.
Children under 5 years old are the most affected by STEC diarrheal infections and have the highest probability of developing STEC-HUS.
The treatment of STEC-HUS is mainly symptomatic, at the moment there are no specific treatments to prevent or control renal damage caused by Stx.
What type of study would your patient be participating in?
The study CT-INM004-04 aims to evaluate the efficacy, safety and pharmacokinetics of INM004 in paediatric patients with Shiga toxin-producing Escherichia coli Hemolytic Uremic Syndrome (STEC-HUS).
The primary objective is to improve renal function, while secondary objectives include reduction of mortality, extrarenal complications, hospital days and improvement of TMA laboratory parameters.
This is a Phase III study involving 220 children between the ages of 9 months and 17 years.
Where will this study be held?
Contact us to choose the site where you would like to refer the patient. We will take care of everything: logistics, accommodation, transport... Just let us know your preferred hospital and make sure the family consents to sharing their personal data with us.
Germany (GER)
- Heidelberg University - University Hospital Cologne (AöR)
Italy (ITA)
- Policlinico di Milan - Policlinico di Bari
Romania (ROM)
- Spitalul Clinic de Urgență pentru Copii Cluj
France (FRA)
- Hopital Femme Mere Enfant, Lyon - Hospital Robert Debre, Paris - Hospital CHU, Bordeaux - Hospital Trousseau, Paris - Hospital Necker, Paris - Centre Hospitalier Universitaire de Montpellier
UK
Royal Hospital for Sick Children (Glasgow) - Bristol Royal Hospital for Children - Great Ormon Street Hospital for Children (London)
Belgium (BEL)
- Cliniques universitaires Saint-Luc – UC Louvain Brussels
Spain (SPN)
- Hospital de Cruces (Barakaldo) - Hospital 12 de Octubre (Madrid)
Ireland (IRL)
- Children’s Health Ireland (CHI). Dublin