It´s a form of thrombotic microangiopathy, characterized by anemia, thrombocytopenia and acute renal impairment of varying severity, which may be preceded by an episode of diarrhea with or without blood.
Children are the most affected by STEC diarrheal infections and have the highest probability of developing STEC-HUS.
The treatment of STEC-Hus is mainly symptomatic, at the moment there are no specific treatments to prevent or control renal damage caused by Stx.
What type of study would your patient be participating in?
The study CT-INM004-04 aims to evaluate the efficacy, safety and pharmacokinetics of INM004 in paediatric patients with Shiga toxin-producing Escherichia coli Hemolytic Uremic Syndrome (STEC-HUS).
The primary objective is to improve renal function, while secondary objectives include reduction of mortality, extrarenal complications, hospital days and improvement of TMA laboratory parameters.
This is a Phase III study involving 220 children between the ages of 9 months and 17 years.
Where will this study be held?
Contact us to choose the site where you would like to refer the patient. We will take care of everything: logistics, accommodation, transport... Just let us know your preferred hospital and make sure the family consents to sharing their personal data with us.
Germany (GER)
- Heidelberg University (Dr Schaefer) - Univ. Medical Center Hamburg-Eppendorf (Dr Sebastian Loos) - University Hospital Cologne (AöR) (Dr. Habbig)
Italy (ITA)
- Policlinico di Milan (Dr. Gianluigi Ardissino) - Policlinico di Bari (Dr. Mario Giordano)
Romania (ROM)
- Spitalul Clinic de Urgență pentru Copii Cluj (Dr. Dan Delean)
France (FRA)
- Hopital Femme Mere Enfant Lyon (Dr Anne Laure Sellier-Leclerc) - Hospital Robert Debre, Paris (Dr KWON Young-Theresa) - Hospital CHU, Bordeaux (Prof. Jerome Harambat) - Hospital Trousseau, Paris (Prof. Tim Ulinski) - Hospital Necker, Paris ( Prof. Olivia Boyer) - Centre Hospitalier Universitaire de Montpellier (Dr. Marc Fila)
UK
Royal Hospital for Sick Children (Glasgow) (Dr. Ben Reynolds) - Bristol Royal Hospital for Children (Dr. Moin Saleem) - Great Ormon Street Hospital for Children (London) (Dr. Jelena Stojanovich)
Belgium (BEL)
- Cliniques universitaires Saint-Luc – UC Louvain Brussels (Nathalie Godefroid)
Spain (SPN)
- Hospital de Cruces (Barakaldo) (Dr. María Herrero Goñi) - Hospital 12 de Octubre (Madrid) (Dra. Mar Espino) - Hospital del Niño Jesús (Madrid) (Dra. Carmen de Lucas)
Ireland (IRL)
- Children’s Health Ireland (CHI). Dublin (Profesor Awan)